PDBsum entry 6cax

Hydrolase/hydrolase inhibitor

PDB id: 6cax

Contents

Protein chain

300 a.a.

Ligands

EUY ×2

EDO ×17

Metals

_ZN ×2

_CL

Waters ×382

PDB id:

6cax

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of lpxc from pseudomonas aeruginosa in complex with pt805

Structure:

Udp-3-o-acyl-n-acetylglucosamine deacetylase. Chain: a. Fragment: psaea.00166.A.Dg15. Synonym: udp-3-o-acyl-glcnac deacetylase,udp-3-o-[r-3- hydroxymyristoyl]-n-acetylglucosamine deacetylase. Engineered: yes

Source:

Pseudomonas aeruginosa. Organism_taxid: 287. Gene: lpxc, ples_47851. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.25Å R-factor: 0.160 R-free: 0.171

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

J.N.Phan et al. Crystal structure of lpxc from pseudomonas aeruginosa complex with pt805. To be published, .

Date:

01-Feb-18 Release date: 13-Feb-19

Protein chain

B7UZI4  (LPXC_PSEA8) -  UDP-3-O-acyl-N-acetylglucosamine deacetylase from Pseudomonas aeruginosa (strain LESB58)

Seq: 303 a.a.

Struc: 300 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.1.108 - UDP-3-O-acyl-N-acetylglucosamine deacetylase.
• Reaction: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate

UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate (Bound ligand (Het Group name = EDO) matches with 60.00% similarity)

• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site