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PDBsum entry 6c1b
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Transferase/transferase inhibitor
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PDB id
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6c1b
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Fgfr1 kinase complex with inhibitor sn37118
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Structure:
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Fibroblast growth factor receptor 1. Chain: a, b. Fragment: unp residues 457-763. Synonym: fgfr-1,basic fibroblast growth factor receptor 1,bfgf-r-1, fms-like tyrosine kinase 2,flt-2,n-sam,proto-oncogenE C-fgr. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.00Å
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R-factor:
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0.222
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R-free:
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0.255
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Authors:
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Y.Yosaatmadja,J.B.Smaill,C.J.Squire
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Date:
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04-Jan-18
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Release date:
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16-Jan-19
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PROCHECK
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Headers
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References
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P11362
(FGFR1_HUMAN) -
Fibroblast growth factor receptor 1 from Homo sapiens
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Seq:
Struc:
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822 a.a.
265 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
