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PDBsum entry 6bb0
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Oxidoreductase
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PDB id
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6bb0
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Lactate dehydrogenase in complex with inhibitor (r)-3-((2- chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one
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Structure:
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L-lactate dehydrogenase a chain. Chain: a, b, c, d. Synonym: ldh-a,cell proliferation-inducing gene 19 protein,ldh muscle subunit,ldh-m,renal carcinoma antigen ny-ren-59. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ldha, pig19. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.95Å
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R-factor:
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0.168
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R-free:
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0.215
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Authors:
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M.Ultsch,C.Eigenbrot
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Key ref:
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B.Wei
et al.
Structure-Guided optimization and in vivo activities hydroxylactone and hydroxylactam inhibitors of human dehydrogenase.
To be published,
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Date:
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16-Oct-17
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Release date:
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24-Oct-18
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PROCHECK
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Headers
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References
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P00338
(LDHA_HUMAN) -
L-lactate dehydrogenase A chain from Homo sapiens
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Seq:
Struc:
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332 a.a.
323 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.1.1.1.27
- L-lactate dehydrogenase.
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Reaction:
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(S)-lactate + NAD+ = pyruvate + NADH + H+
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(S)-lactate
Bound ligand (Het Group name = )
corresponds exactly
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+
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NAD(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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pyruvate
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+
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NADH
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
