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PDBsum entry 6b8e
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PDB id:
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Hydrolase
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Title:
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Multiconformer model of apo wt ptp1b with glycerol at 180 k
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Structure:
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Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: catalytic domain. Synonym: protein-tyrosine phosphatase 1b,ptp-1b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn1, ptp1b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.82Å
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R-factor:
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0.172
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R-free:
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0.200
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Authors:
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D.A.Keedy,Z.B.Hill,J.T.Biel,E.Kang,T.J.Rettenmaier,J.Brandao-Neto, F.Von Delft,J.A.Wells,J.S.Fraser
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Key ref:
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D.A.Keedy
et al.
(2018).
An expanded allosteric network in ptp1b by multitempe crystallography, Fragment screening, And covalent tet.
Elife,
7,
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PubMed id:
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Date:
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06-Oct-17
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Release date:
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20-Jun-18
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PROCHECK
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Headers
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References
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P18031
(PTN1_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 1 from Homo sapiens
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Seq:
Struc:
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435 a.a.
298 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
