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PDBsum entry 6csb
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Oxidoreductase
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PDB id
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6csb
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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V308e mutant of cytochrome p450 2d6 complexed with thioridazine
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Structure:
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Cytochrome p450 2d6. Chain: a, b, c, d. Fragment: residues 34-497. Synonym: cypiid6,cholesterol 25-hydroxylase,cytochrome p450-db1, debrisoquine 4-hydroxylase. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cyp2d6, cyp2dl1. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.39Å
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R-factor:
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0.195
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R-free:
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0.229
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Authors:
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Y.T.Yang,K.Fujita,P.F.Wang,S.C.Im,N.M.Pearl,J.Meagher,J.Stuckey, L.Waskell
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Key ref:
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Y.T.Yang
et al.
Characteristic conformational changes on the distal a proximal surfaces of cytochrome p450 2d6 in response substrate binding.
To be published,
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Date:
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20-Mar-18
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Release date:
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27-Mar-19
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PROCHECK
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Headers
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References
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P10635
(CP2D6_HUMAN) -
Cytochrome P450 2D6 from Homo sapiens
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Seq:
Struc:
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497 a.a.
452 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 7 residue positions (black
crosses)
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Links
