PDBsum entry 5ydh

Hydrolase

PDB id: 5ydh

Contents

Protein chains

538 a.a.

Ligands

NAG-NAG-BMA-MAN

NAG-NAG-BMA-MAN-MAN

SO4 ×26

NAG ×2

EPE ×3

GOL ×3

Metals

_CO ×2

Waters ×12

PDB id:

5ydh

Name:

Hydrolase

Title:

Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector anopheles gambiae, 3.2 a

Structure:

Acetylcholinesterase. Chain: a, b. Fragment: unp residues 162-737. Synonym: ache. Engineered: yes

Source:

Anopheles gambiae. African malaria mosquito. Organism_taxid: 7165. Gene: ace, ace1, ache1, agap001356. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.

Resolution:

3.21Å R-factor: 0.208 R-free: 0.231

Authors:

Q.Han,H.Guan,H.Robinson,H.Ding,C.Liao,J.Li

Date:

13-Sep-17 Release date: 07-Mar-18

Protein chains

Q869C3  (ACES_ANOGA) -  Acetylcholinesterase from Anopheles gambiae

Seq: 737 a.a.

Struc: 538 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.7 - acetylcholinesterase.
• Reaction: acetylcholine + H2O = choline + acetate + H⁺

acetylcholine (Bound ligand (Het Group name = NAG) matches with 41.18% similarity) + H2O = choline (Bound ligand (Het Group name = GOL) matches with 42.86% similarity) + acetate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site