PDBsum entry 5uuk

Apoptosis

PDB id: 5uuk

Contents

Protein chains

152 a.a.

23 a.a.

Ligands

SO4 ×2

Waters ×144

PDB id:

5uuk

Name:

Apoptosis

Title:

Human bfl-1 in complex with a bfl-1-specific selected peptide

Structure:

Bcl-2-related protein a1. Chain: a. Fragment: unp residues 1-151. Synonym: bcl-2-like protein 5,bcl2-l-5,hemopoietic-specific early response protein,protein bfl-1,protein grs. Engineered: yes. Bfl-1-specific selected peptide. Chain: b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bcl2a1, bcl2l5, bfl1, grs, hbpa1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

1.20Å R-factor: 0.144 R-free: 0.163

Authors:

J.M.Jenson,R.A.Grant,A.E.Keating

Key ref:

J.M.Jenson et al. (2017). Epistatic mutations in puma bh3 drive an alternate bi mode to potently and selectively inhibit anti-Apoptot bfl-1.. Elife, 6, . PubMed id: 28594323

Date:

17-Feb-17 Release date: 21-Jun-17

Protein chain

Q16548  (B2LA1_HUMAN) -  Bcl-2-related protein A1 from Homo sapiens

Seq: 175 a.a.

Struc: 152 a.a.

Protein chain

No UniProt id for this chain

Struc: 22 a.a.