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PDBsum entry 5upd
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PDB id:
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Transferase
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Title:
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Methyltransferase domain of human wolf-hirschhorn syndrome candidate 1-like protein 1 (whsc1l1)
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Structure:
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Histone-lysine n-methyltransferase nsd3. Chain: a. Synonym: nuclear set domain-containing protein 3,protein whistle, whsc1-like 1 isoform 9 with methyltransferase activity to lysine, wolf-hirschhorn syndrome candidate 1-like protein 1,whsc1-like protein 1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: whsc1l1, nsd3, dc28. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.80Å
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R-factor:
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0.186
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R-free:
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0.218
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Authors:
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W.Tempel,W.Yu,A.Dong,T.Cerovina,C.Bountra,C.H.Arrowsmith,A.M.Edwards, P.J.Brown,H.Wu,Structural Genomics Consortium (Sgc)
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Key ref:
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W.Tempel
et al.
Methyltransferase domain of human wolf-Hirschhorn syn candidate 1-Like protein 1 (whsc1l1).
To be published,
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Date:
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02-Feb-17
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Release date:
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15-Feb-17
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Supersedes:
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PROCHECK
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Headers
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References
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Q9BZ95
(NSD3_HUMAN) -
Histone-lysine N-methyltransferase NSD3 from Homo sapiens
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Seq:
Struc:
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1437 a.a.
214 a.a.
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Enzyme class 1:
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E.C.2.1.1.370
- [histone H3]-lysine(4) N-dimethyltransferase.
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Reaction:
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L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = N6,N6-dimethyl- L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H+
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L-lysyl(4)-[histone H3]
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+
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2
×
S-adenosyl-L-methionine
Bound ligand (Het Group name = )
corresponds exactly
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=
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N(6),N(6)-dimethyl- L-lysyl(4)-[histone H3]
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+
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2
×
S-adenosyl-L-homocysteine
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+
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2
×
H(+)
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Enzyme class 2:
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E.C.2.1.1.371
- [histone H3]-lysine(27) N-dimethyltransferase.
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Reaction:
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L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = N6,N6- dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H+
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L-lysyl(27)-[histone H3]
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+
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2
×
S-adenosyl-L-methionine
Bound ligand (Het Group name = )
corresponds exactly
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=
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N(6),N(6)- dimethyl-L-lysyl(27)-[histone H3]
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+
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2
×
S-adenosyl-L-homocysteine
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+
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2
×
H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
