PDBsum entry 5uml

Cell cycle,antitumor protein/inhibitor

PDB id: 5uml

Contents

Protein chains

84 a.a.

11 a.a.

PDB id:

5uml

Name:

Cell cycle,antitumor protein/inhibitor

Title:

Crystal structure of human mdmx in complex with 12-mer peptide inhibitor m3

Structure:

Protein mdm4. Chain: a, b, e, g. Fragment: residues 24-108. Synonym: double minute 4 protein,mdm2-like p53-binding protein, protein mdmx,p53-binding protein mdm4. Engineered: yes. Mutation: yes. Peptide inhibitor m3. Chain: c, d, f, h.

Source:

Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Synthetic construct. Organism_taxid: 32630

Resolution:

3.00Å R-factor: 0.261 R-free: 0.315

Authors:

M.Pazgier,N.Gohain,W.D.Tolbert

Key ref:

P.Marzena et al. Design of ultrahigh-Affinity and dual-Specificity pep antagonists of mdm2 and mdmx for p53 activation. To be published, .

Date:

27-Jan-17 Release date: 31-Jan-18

Protein chains

O15151  (MDM4_HUMAN) -  Protein Mdm4 from Homo sapiens

Seq: 490 a.a.

Struc: 84 a.a.*

Protein chains

No UniProt id for this chain

Struc: 11 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)