PDBsum entry 5ugx

Transferase

PDB id: 5ugx

Contents

Protein chains

282 a.a.

297 a.a.

Ligands

SO4 ×4

ACP ×2

Metals

_MG ×2

Waters ×38

PDB id:

5ugx

Name:

Transferase

Title:

Crystal structure of the tyrosine kinase domain of fgf receptor 2 harboring a e565a/d650v double gain-of-function mutation

Structure:

Fibroblast growth factor receptor 2. Chain: b, a. Fragment: unp residues 341-651. Synonym: fgfr-2,k-sam,kgfr,keratinocyte growth factor receptor. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.35Å R-factor: 0.220 R-free: 0.275

Authors:

M.Mohammadi,H.Chen

Key ref:

H.Chen et al. (2017). Elucidation of a four-Site allosteric network in fibr growth factor receptor tyrosine kinases.. Elife, 6, . PubMed id: 28166054

Date:

10-Jan-17 Release date: 22-Feb-17

Protein chain

P21802  (FGFR2_HUMAN) -  Fibroblast growth factor receptor 2 from Homo sapiens

Seq: 821 a.a.

Struc: 282 a.a.*

Protein chain

P21802  (FGFR2_HUMAN) -  Fibroblast growth factor receptor 2 from Homo sapiens

Seq: 821 a.a.

Struc: 297 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains B, A: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = ACP) matches with 81.25% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site