PDBsum entry 5u3d

Immune system

PDB id: 5u3d

Contents

Protein chains

214 a.a.

221 a.a.

63 a.a.

54 a.a.

Ligands

MRY

Waters ×803

PDB id:

5u3d

Name:

Immune system

Title:

Structure of meditope enabled trastuzumab i83e variant

Structure:

Memab trastuzumab fab light chain i83e. Chain: a. Engineered: yes. Memab trastuzumab fab heavy chain. Chain: b. Engineered: yes. Protein l. Chain: e. Engineered: yes.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Finegoldia magna. Peptostreptococcus magnus. Organism_taxid: 1260. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.77Å R-factor: 0.158 R-free: 0.185

Authors:

K.P.Bzymek,K.N.Avery,C.Zer,J.C.Williams

Key ref:

K.P.Bzymek et al. Meditope enabled trastuzumab i83e variant. To be published, .

Date:

01-Dec-16 Release date: 14-Mar-18

Protein chain

No UniProt id for this chain

Struc: 214 a.a.

Protein chain

No UniProt id for this chain

Struc: 221 a.a.

Protein chain

Q51918  (Q51918_FINMA) -  Protein L from Finegoldia magna

Seq: 992 a.a.

Struc: 63 a.a.*

Protein chain

P02976  (SPA_STAA8) -  Immunoglobulin G-binding protein A from Staphylococcus aureus (strain NCTC 8325 / PS 47)

Seq: 516 a.a.

Struc: 54 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)