PDBsum entry 5u1d

Transport protein

PDB id: 5u1d

Contents

Protein chains

561 a.a.

552 a.a.

55 a.a.

PDB id:

5u1d

Name:

Transport protein

Title:

Cryo-em structure of the human tap atp-binding cassette transporter

Structure:

Antigen peptide transporter 1. Chain: a. Synonym: apt1, atp-binding cassette sub-family b member 2, peptide supply factor 1, peptide transporter psf1, psf-1, peptide transporter tap1, peptide transporter involved in antigen processing 1, really interesting new gene 4 protein. Engineered: yes. Antigen peptide transporter 2. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tap1, abcb2, psf1, ring4, y3. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Gene: tap2, abcb3, psf2, ring11, y1. Human herpesvirus 1. Hhv-1.

Authors:

M.L.Oldham,J.Chen,N.Grigorieff

Key ref:

M.L.Oldham et al. (2016). Structure of the transporter associated with antigen processing trapped by herpes simplex virus.. Elife, 5, . PubMed id: 27935481

Date:

28-Nov-16 Release date: 11-Jan-17

Protein chain

Q03518  (TAP1_HUMAN) -  Antigen peptide transporter 1 from Homo sapiens

Seq: 748 a.a.

Struc: 561 a.a.

Protein chain

Q03519  (TAP2_HUMAN) -  Antigen peptide transporter 2 from Homo sapiens

Seq: 686 a.a.

Struc: 552 a.a.

Protein chain

A0A140GKJ0  (A0A140GKJ0_HHV1) -  ICP47 protein from Human herpesvirus 1

Seq: 88 a.a.

Struc: 55 a.a.

Enzyme reactions

• Enzyme class 2: Chains A, B: E.C.7.4.2.14 - ABC-type antigen peptide transporter.
• Reaction: a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H⁺
• Enzyme class 3: Chain X: E.C.?

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site