PDBsum entry 5tqw

Transferase

PDB id: 5tqw

Contents

Protein chains

564 a.a.

PDB id:

5tqw

Name:

Transferase

Title:

Cryoem reconstruction of human ikk1, open conformation 1

Structure:

Inhibitor of nuclear factor kappa-b kinase subunit alpha. Chain: a, b. Synonym: ikappab kinase, conserved helix-loop-helix ubiquitous kinase, i-kappa-b kinase 1, ikk1, nuclear factor nf-kappa-b inhibitor kinase alpha, nfkbika, transcription factor 16, tcf-16. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: chuk, ikka, tcf16. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

D.Lyumkis,G.Ghosh,S.Polley,T.Biswath,D.Huang,D.O.Passos

Key ref:

S.Polley et al. (2016). Structural Basis for the Activation of IKK1/α. Cell Rep, 17, 1907-1914. PubMed id: 27851956 DOI: 10.1016/j.celrep.2016.10.067

Date:

24-Oct-16 Release date: 09-Nov-16

Protein chains

O15111  (IKKA_HUMAN) -  Inhibitor of nuclear factor kappa-B kinase subunit alpha from Homo sapiens

Seq: 745 a.a.

Struc: 564 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.10 - IkappaB kinase.
• Reaction: L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.celrep.2016.10.067

Cell Rep 17:1907-1914 (2016)

PubMed id: 27851956

Structural Basis for the Activation of IKK1/α.

S.Polley, D.O.Passos, D.B.Huang, M.C.Mulero, A.Mazumder, T.Biswas, I.M.Verma, D.Lyumkis, G.Ghosh.

ABSTRACT

No abstract given.