PDBsum entry 5tob

Transferase/transferase inhibitor

PDB id: 5tob

Contents

Protein chain

245 a.a.

Ligands

YAM

Waters ×122

PDB id:

5tob

Name:

Transferase/transferase inhibitor

Title:

Selectivity switch between fak and pyk2: macrocyclization of fak inhibitors improves pyk2 potency

Structure:

Protein-tyrosine kinase 2-beta. Chain: a. Fragment: unp residues 414-692. Synonym: calcium-dependent tyrosine kinase,cadtk,calcium-regulated non-receptor proline-rich tyrosine kinase,cell adhesion kinase beta, cakb,focal adhesion kinase 2,fadk 2,proline-rich tyrosine kinase 2, related adhesion focal tyrosine kinase,raftk. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.12Å R-factor: 0.212 R-free: 0.262

Authors:

Z.E.Newby

Key ref:

J.Farand et al. (2016). Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency. Bioorg Med Chem Lett, 26, 5926-5930. PubMed id: 27876318 DOI: 10.1016/j.bmcl.2016.10.092

Date:

17-Oct-16 Release date: 29-Nov-17

Protein chain

Q14289  (FAK2_HUMAN) -  Protein-tyrosine kinase 2-beta from Homo sapiens

Seq: 1009 a.a.

Struc: 245 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1016/j.bmcl.2016.10.092

Bioorg Med Chem Lett 26:5926-5930 (2016)

PubMed id: 27876318

Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.

J.Farand, N.Mai, J.Chandrasekhar, Z.E.Newby, J.Van Veldhuizen, J.Loyer-Drew, C.Venkataramani, J.Guerrero, A.Kwok, N.Li, Y.Zherebina, S.Wilbert, J.Zablocki, G.Phillips, W.J.Watkins, R.Mourey, G.T.Notte.

ABSTRACT

No abstract given.