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PDBsum entry 5tcc
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Hydrolase/hydrolase inhibitor
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PDB id
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5tcc
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Complement factor d inhibited with jh4
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Structure:
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Complement factor d. Chain: a, b, c, d, e, f, g. Fragment: residues 26-253. Synonym: adipsin,c3 convertase activator,properdin factor d. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cfd, df, pfd. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
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Resolution:
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3.37Å
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R-factor:
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0.242
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R-free:
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0.260
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Authors:
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J.A.Stuckey
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Key ref:
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C.Y.Yang
et al.
(2016).
Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.
Acs Med Chem Lett,
7,
1092-1096.
PubMed id:
DOI:
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Date:
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14-Sep-16
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Release date:
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19-Oct-16
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PROCHECK
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Headers
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References
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P00746
(CFAD_HUMAN) -
Complement factor D from Homo sapiens
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Seq:
Struc:
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253 a.a.
228 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.21.46
- complement factor D.
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Reaction:
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Cleaves component factor B (Arg-|-Lys) when in complex with C3b or with cobra venom factor (CVF).
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DOI no:
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Acs Med Chem Lett
7:1092-1096
(2016)
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PubMed id:
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Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.
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C.Y.Yang,
J.G.Phillips,
J.A.Stuckey,
L.Bai,
H.Sun,
J.Delproposto,
W.C.Brown,
K.Chinnaswamy.
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ABSTRACT
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Links
