PDBsum entry 5t7f

Transferase/transferase inhibitor

PDB id: 5t7f

Contents

Protein chains

819 a.a.

Ligands

76C ×2

Waters ×95

PDB id:

5t7f

Name:

Transferase/transferase inhibitor

Title:

Pi3kdelta in complex with the inhibitor gs-643624

Structure:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform. Chain: a, b. Fragment: unp residues 106-1043. Synonym: ptdins-3-kinase subunit delta,phosphatidylinositol 4,5- bisphosphate 3-kinase 110 kda catalytic subunit delta,p110delta. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: pik3cd. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.60Å R-factor: 0.230 R-free: 0.294

Authors:

J.R.Somoza,A.Villasenor

Key ref:

L.Patel et al. The discovery of gs-9901: a potent, Selective and metabolically stable inhibitor of pi3kd. To be published, .

Date:

04-Sep-16 Release date: 28-Dec-16

Protein chains

O35904  (PK3CD_MOUSE) -  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform from Mus musculus

Seq: 1043 a.a.

Struc: 819 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.7.1.137 - phosphatidylinositol 3-kinase.
• Pathway: 1-Phosphatidyl-myo-inositol Metabolism
• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H⁺
• Enzyme class 3: E.C.2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase.

Pathway:

• Reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + ADP + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site