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PDBsum entry 5skh
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Hydrolase/hydrolase inhibitor
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PDB id
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5skh
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Crystal structure of human phosphodiesterase 10 in complex with c1=cn(n=c(c1=o)c2ccnn2c3cc(ccc3)f)c4cc(ccc4)oc(f)(f)f, micromolar ic50=0.043256
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Structure:
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Camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase 10a. Chain: a, b, c, d. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pde10a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.10Å
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R-factor:
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0.196
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R-free:
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0.237
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Authors:
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C.Joseph,J.Benz,A.Flohr,M.Rogers-Evans,M.G.Rudolph
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Key ref:
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A.Flohr
et al.
Crystal structure of a human phosphodiesterase 10 com.
To be published,
.
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Date:
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01-Feb-22
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Release date:
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12-Oct-22
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PROCHECK
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Headers
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References
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Q9Y233
(PDE10_HUMAN) -
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A from Homo sapiens
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Seq:
Struc:
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1055 a.a.
313 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.1.4.17
- 3',5'-cyclic-nucleotide phosphodiesterase.
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Reaction:
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a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H+
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nucleoside 3',5'-cyclic phosphate
Bound ligand (Het Group name = )
matches with 46.15% similarity
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+
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H2O
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=
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nucleoside 5'-phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
