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PDBsum entry 5rxt
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PDB id:
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Hydrolase
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Title:
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Inpp5d pandda analysis group deposition -- crystal structure of the phosphatase and c2 domains of ship1 in complex with z319545618
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Structure:
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. Chain: a. Synonym: inositol polyphosphate-5-phosphatase d,inositol polyphosphate-5-phosphatase of 145 kda,sip-145,phosphatidylinositol 4,5-bisphosphate 5-phosphatase,sh2 domain-containing inositol 5'- phosphatase 1,ship-1,p150ship,hp51cn. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: inpp5d, ship, ship1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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1.63Å
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R-factor:
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0.189
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R-free:
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0.218
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Authors:
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W.J.Bradshaw,J.A.Newman,F.Von Delft,C.H.Arrowsmith,A.M.Edwards, C.Bountra,O.Gileadi
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Key ref:
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W.J.Bradshaw
et al.
Inpp5d pandda analysis group deposition.
To be published,
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PubMed id:
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Date:
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30-Oct-20
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Release date:
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11-Nov-20
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PROCHECK
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Headers
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References
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Q92835
(SHIP1_HUMAN) -
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 from Homo sapiens
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Seq:
Struc:
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1189 a.a.
460 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.3.1.3.36
- phosphoinositide 5-phosphatase.
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Pathway:
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1-Phosphatidyl-myo-inositol Metabolism
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
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+
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H2O
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=
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)
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+
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phosphate
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Enzyme class 3:
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E.C.3.1.3.56
- inositol-polyphosphate 5-phosphatase.
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Pathway:
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Reaction:
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1.
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1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4- bisphosphate + phosphate
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2.
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1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
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1D-myo-inositol 1,4,5-trisphosphate
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+
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H2O
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=
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1D-myo-inositol 1,4- bisphosphate
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+
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phosphate
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1D-myo-inositol 1,3,4,5-tetrakisphosphate
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+
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H2O
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=
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1D-myo-inositol 1,3,4-trisphosphate
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+
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phosphate
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Enzyme class 4:
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E.C.3.1.3.86
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4- bisphosphate) + phosphate
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)
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+
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H2O
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=
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4- bisphosphate)
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+
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phosphate
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
