PDBsum entry 5r3c

Hydrolase

PDB id: 5r3c

Contents

Protein chain

330 a.a.

Waters ×325

PDB id:

5r3c

Name:

Hydrolase

Title:

Pandda analysis group deposition -- auto-refined data of endothiapepsin for ground state model 36, dmso-free

Structure:

Endothiapepsin. Chain: a. Synonym: aspartate protease. Ec: 3.4.23.22

Source:

Cryphonectria parasitica. Chestnut blight fungus. Organism_taxid: 5116. Other_details: cell

Resolution:

0.95Å R-factor: 0.122 R-free: 0.129

Authors:

J.Wollenhaupt,A.Metz,T.Barthel,G.M.A.Lima,A.Heine,U.Mueller,G.Klebe, M.S.Weiss

Date:

11-Mar-20 Release date: 03-Jun-20

Protein chain

P11838  (CARP_CRYPA) -  Endothiapepsin from Cryphonectria parasitica

Seq: 419 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.22 - endothiapepsin.
• Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.