PDBsum entry 5p9c

Transferase

PDB id: 5p9c

Contents

Protein chain

213 a.a.

Ligands

77Q

SO4

D1D

Metals

_MG

__K

Waters ×275

PDB id:

5p9c

Name:

Transferase

Title:

Rat catechol o-methyltransferase in complex with 5-(4-fluorophenyl)-2, 3-dihydroxy-n-(5-pyrrolo[3,2-c]pyridin-1-ylpentyl)benzamide at 1.70a

Structure:

Catechol o-methyltransferase. Chain: a. Fragment: soluble form, residues 44-264. Engineered: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: comt. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.221 R-free: 0.270

Authors:

A.Ehler,C.Lerner,M.G.Rudolph

Key ref:

C.Lerner and m.g.rudolph Crystal structure of a comt complex. To be published, .

Date:

30-Aug-16 Release date: 30-Aug-17

Protein chain

P22734  (COMT_RAT) -  Catechol O-methyltransferase from Rattus norvegicus

Seq: 264 a.a.

Struc: 213 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.6 - catechol O-methyltransferase.
• Reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L- homocysteine + H⁺

catechol (Bound ligand (Het Group name = D1D) matches with 60.00% similarity) + S-adenosyl-L-methionine = guaiacol + S-adenosyl-L- homocysteine + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site