PDBsum entry 5olm

Antiviral protein

PDB id: 5olm

Contents

Protein chains

125 a.a.

132 a.a.

Metals

_ZN ×8

Waters ×37

PDB id:

5olm

Name:

Antiviral protein

Title:

Trim21

Structure:

E3 ubiquitin-protein ligase trim21. Chain: a, b. Synonym: 52 kda ro protein,52 kda ribonucleoprotein autoantigen ro/ss-a,ring finger protein 81,ring-type e3 ubiquitin transferase trim21,ro(ss-a),sjoegren syndrome type a antigen,ss-a,tripartite motif-containing protein 21. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trim21, rnf81, ro52, ssa1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.95Å R-factor: 0.211 R-free: 0.262

Authors:

L.C.James

Key ref:

C.Dickson et al. (2018). Intracellular antibody signalling is regulated by phosphorylation of the fc receptor trim21.. Elife, 7, . PubMed id: 29667579

Date:

28-Jul-17 Release date: 25-Apr-18

Protein chain

P19474  (RO52_HUMAN) -  E3 ubiquitin-protein ligase TRIM21 from Homo sapiens

Seq: 475 a.a.

Struc: 125 a.a.

Protein chain

P19474  (RO52_HUMAN) -  E3 ubiquitin-protein ligase TRIM21 from Homo sapiens

Seq: 475 a.a.

Struc: 132 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine