PDBsum entry 5oaz

Transferase

PDB id: 5oaz

Contents

Protein chains

59 a.a.

56 a.a.

Ligands

PEG ×3

Waters ×124

PDB id:

5oaz

Name:

Transferase

Title:

Crystal structure of the abl-sh3 domain at ph 7.5

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Fragment: sh3 domain. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.03Å R-factor: 0.146 R-free: 0.163

Authors:

A.Camara-Artigas

Key ref:

A.Camara-Artigas Crystal structure of the abl-Sh3 domain at ph 7.5. To be published, .

Date:

25-Jun-17 Release date: 12-Jul-17

Protein chain

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 59 a.a.

Protein chain

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 56 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site