PDBsum entry 5nqk

Immune system

PDB id: 5nqk

Contents

Protein chains

275 a.a.

100 a.a.

197 a.a.

243 a.a.

Ligands

GLU-LEU-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL

Metals

_NA

PDB id:

5nqk

Name:

Immune system

Title:

Human 199.16 tcr in complex with melan-a/mart-1 (26-35) peptide and hla-a2

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: h. Synonym: mhc class i antigen a 2. Engineered: yes. Mutation: yes. Beta-2-microglobulin. Chain: l. Engineered: yes. Melanoma antigen recognized by t-cells 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: x90f laqq1. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.

Resolution:

3.25Å R-factor: 0.228 R-free: 0.316

Authors:

C.Exertier,J.-B.Reiser,V.Lantez,A.Chouquet,M.Bonneville,X.Saulquin, D.Housset

Key ref:

C.Exertier et al. Human 199.16 tcr in complex with melan-A/mart-1 (26-3 peptide and hla-A2. To be published, .

Date:

20-Apr-17 Release date: 30-May-18

Protein chain

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

Protein chain

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 197 a.a.*

Protein chain

A0A075B6N1  (A0A075B6N1_HUMAN) -  T cell receptor beta variable 19 from Homo sapiens

Seq: 114 a.a.

Struc: 243 a.a.*

* PDB and UniProt seqs differ at 23 residue positions (black crosses)