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PDBsum entry 5ml5
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PDB id:
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Transferase
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Title:
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Human p38alpha mapk in complex with imidazolyl pyridine inhibitor 11b
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Structure:
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Mitogen-activated protein kinase 14. Chain: a. Synonym: mapk 14,cytokine suppressive anti-inflammatory drug-binding protein,csbp,map kinase mxi2,max-interacting protein 2,mitogen- activated protein kinase p38 alpha,map kinase p38 alpha,stress- activated protein kinase 2a,sapk2a. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.90Å
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R-factor:
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0.195
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R-free:
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0.240
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Authors:
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M.Buehrmann,D.Rauh
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Key ref:
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J.Halekotte
et al.
(2017).
Optimized 4,5-Diarylimidazoles as potent/selective inhibitors of protein kinase ck1 delta and their stru relation to p38 alpha mapk..
Molecules,
22,
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PubMed id:
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Date:
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06-Dec-16
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Release date:
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05-Apr-17
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PROCHECK
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Headers
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References
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Q16539
(MK14_HUMAN) -
Mitogen-activated protein kinase 14 from Homo sapiens
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Seq:
Struc:
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360 a.a.
326 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.11.24
- mitogen-activated protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
