PDBsum entry 5ml2

Lipid binding protein

PDB id: 5ml2

Contents

Protein chain

144 a.a.

Ligands

NH6

Waters ×131

PDB id:

5ml2

Name:

Lipid binding protein

Title:

The crystal structure of pde6d in complex with inhibitor-3

Structure:

Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit delta. Chain: b. Synonym: gmp-pde delta,protein p17. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde6d, pded. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.60Å R-factor: 0.204 R-free: 0.227

Authors:

E.K.Fansa,P.Martin-Gago,H.Waldmann,A.Wittinghofer

Key ref:

P.Martín-Gago et al. (2017). A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angew Chem Int Ed Engl, 56, 2423-2428. PubMed id: 28106325 DOI: 10.1002/anie.201610957

Date:

06-Dec-16 Release date: 01-Feb-17

Protein chain

O43924  (PDE6D_HUMAN) -  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta from Homo sapiens

Seq: 150 a.a.

Struc: 144 a.a.

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1002/anie.201610957

Angew Chem Int Ed Engl 56:2423-2428 (2017)

PubMed id: 28106325

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

P.Martín-Gago, E.K.Fansa, C.H.Klein, S.Murarka, P.Janning, M.Schürmann, M.Metz, S.Ismail, C.Schultz-Fademrecht, M.Baumann, P.I.Bastiaens, A.Wittinghofer, H.Waldmann.

ABSTRACT

No abstract given.