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PDBsum entry 5l4h
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Membrane protein, transport protein
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PDB id
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5l4h
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PDB id:
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| Name: |
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Membrane protein, transport protein
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Title:
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X-ray structure of the 2-22' locally-closed mutant of glic in complex with 5-(2-bromo-ethyl)-5-ethyl-pyrimidine-2,4,6-trione (brominated barbiturate)
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Structure:
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Proton-gated ion channel. Chain: a, b, c, d, e. Synonym: glic,ligand-gated ion channel,lgic. Engineered: yes
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Source:
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Gloeobacter violaceus (strain pcc 7421). Organism_taxid: 251221. Strain: pcc 7421. Gene: glvi, glr4197. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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3.30Å
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R-factor:
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0.215
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R-free:
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0.235
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Authors:
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Z.Fourati,R.R.Ruza,M.Delarue
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Key ref:
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Z.Fourati
et al.
(2017).
Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
J Biol Chem,
292,
1550-1558.
PubMed id:
DOI:
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Date:
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25-May-16
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Release date:
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21-Dec-16
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PROCHECK
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Headers
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References
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Q7NDN8
(GLIC_GLOVI) -
Proton-gated ion channel from Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
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Seq:
Struc:
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359 a.a.
311 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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DOI no:
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J Biol Chem
292:1550-1558
(2017)
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PubMed id:
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Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
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Z.Fourati,
R.R.Ruza,
D.Laverty,
E.Drège,
S.Delarue-Cochin,
D.Joseph,
P.Koehl,
T.Smart,
M.Delarue.
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ABSTRACT
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Links
