PDBsum entry 5l2k

Immune system

PDB id: 5l2k

Contents

Protein chains

276 a.a.

98 a.a.

185 a.a.

242 a.a.

Ligands

NAG ×3

SO4 ×5

6UL

70E

Metals

_CL ×4

_CS

_NA ×2

Waters ×6

PDB id:

5l2k

Name:

Immune system

Title:

Crystal structure of gem42 tcr-cd1b-gmm complex

Structure:

T-cell surface glycoprotein cd1b. Chain: a. Engineered: yes. Mutation: yes. Beta-2-microglobulin. Chain: b. Engineered: yes. Gem42 tcr alpha chain. Chain: d.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cd1b. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s. Gene: b2m, cdabp0092, hdcma22p. Expressed in: escherichia coli.

Resolution:

3.20Å R-factor: 0.219 R-free: 0.239

Authors:

S.Gras,A.Shahine,J.Le Nours,J.Rossjohn

Key ref:

S.Gras et al. (2016). T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun, 7, 13257. PubMed id: 27807341 DOI: 10.1038/ncomms13257

Date:

02-Aug-16 Release date: 16-Nov-16

Protein chain

P29016  (CD1B_HUMAN) -  T-cell surface glycoprotein CD1b from Homo sapiens

Seq: 333 a.a.

Struc: 276 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 98 a.a.

Protein chain

No UniProt id for this chain

Struc: 185 a.a.

Protein chain

No UniProt id for this chain

Struc: 242 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1038/ncomms13257

Nat Commun 7:13257 (2016)

PubMed id: 27807341

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

S.Gras, I.Van Rhijn, A.Shahine, T.Y.Cheng, M.Bhati, L.L.Tan, H.Halim, K.D.Tuttle, L.Gapin, J.Le Nours, D.B.Moody, J.Rossjohn.

ABSTRACT

No abstract given.