PDBsum entry 5kql

Hydrolase/hydrolase inhibitor

PDB id: 5kql

Contents

Protein chain

154 a.a.

Ligands

6VY

Waters ×268

PDB id:

5kql

Name:

Hydrolase/hydrolase inhibitor

Title:

Co-crystal structure of lmw-ptp in complex with 2-oxo-1-phenyl-2- (phenylamino)ethanesulfonic acid

Structure:

Low molecular weight phosphotyrosine protein phosphatase. Chain: a. Synonym: lmw-ptpase,adipocyte acid phosphatase,low molecular weight cytosolic acid phosphatase,red cell acid phosphatase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: acp1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.45Å R-factor: 0.165 R-free: 0.177

Authors:

J.Wang,Z.-Y.Zhang,Z.-H.Yu

Key ref:

R.He et al. Inhibition of low molecular weight protein tyrosine phosphatase by an induced-Fit mechanism.. J med chem, . PubMed id: 27676368

Date:

06-Jul-16 Release date: 12-Oct-16

Protein chain

P24666  (PPAC_HUMAN) -  Low molecular weight phosphotyrosine protein phosphatase from Homo sapiens

Seq: 158 a.a.

Struc: 154 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.1.3.2 - acid phosphatase.
• Reaction: a phosphate monoester + H2O = an alcohol + phosphate
• Enzyme class 3: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site