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PDBsum entry 5jsv
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PDB id:
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Transferase
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Title:
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tRNA guanine transglycosylase (tgt) in co-crystallized complex with 6- amino-2-((((3ar,4r,6r,6ar)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4- d][1,3]dioxol-4-yl)methyl)amino)-1h-imidazo[4,5-g]quinazolin-8(7h)- one
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Structure:
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Queuine tRNA-ribosyltransferase. Chain: a. Synonym: guanine insertion enzyme,tRNA-guanine transglycosylase. Engineered: yes
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Source:
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Zymomonas mobilis subsp. Mobilis zm4 = atcc 31821. Organism_taxid: 264203. Gene: tgt, zmo0363. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.17Å
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R-factor:
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0.122
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R-free:
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0.139
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Authors:
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F.R.Ehrmann,D.Nguyen,A.Heine,G.Klebe
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Key ref:
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F.R.Ehrmann
et al.
Application of carbohydrates based lin-Benzoguanines solvent-Exposed subpocket of the tRNA-Modifying enzym.
To be published,
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Date:
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09-May-16
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Release date:
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24-May-17
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PROCHECK
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Headers
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References
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P28720
(TGT_ZYMMO) -
Queuine tRNA-ribosyltransferase from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
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Seq:
Struc:
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386 a.a.
370 a.a.*
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Key: |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.4.2.29
- tRNA-guanosine(34) preQ1 transglycosylase.
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Reaction:
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7-aminomethyl-7-carbaguanine + guanosine34 in tRNA = 7-aminomethyl-7- carbaguanosine34 in tRNA + guanine
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7-aminomethyl-7-carbaguanine
Bound ligand (Het Group name = )
matches with 40.00% similarity
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+
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guanosine(34) in tRNA
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=
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7-aminomethyl-7- carbaguanosine(34) in tRNA
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+
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guanine
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
