PDBsum entry 5iv0

Transferase/transferase inhibitor

PDB id: 5iv0

Contents

Protein chain

396 a.a.

Ligands

COA

6E9

Metals

_CL ×3

Waters ×237

PDB id:

5iv0

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of eis from mycobacterium tuberculosis in complex with sulfonamide inhibitor 39 and coenzyme a

Structure:

Enhanced intracellular survival protein. Chain: a. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis (strain cdc 1551 / oshkosh). Organism_taxid: 83331. Strain: cdc 1551 / oshkosh. Gene: eis, mt2489. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.10Å R-factor: 0.193 R-free: 0.219

Authors:

C.S.Gajadeera,C.Hou,S.Garneau-Tsodikova,O.V.Tsodikov

Key ref:

A.Garzan et al. (2016). Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis. J Med Chem, 59, 10619-10628. PubMed id: 27933949 DOI: 10.1021/acs.jmedchem.6b01161

Date:

18-Mar-16 Release date: 11-Jan-17

Protein chain

P9WFK7  (EIS_MYCTU) -  N-acetyltransferase Eis from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 402 a.a.

Struc: 396 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.3.1.- - ?????

DOI no: 10.1021/acs.jmedchem.6b01161

J Med Chem 59:10619-10628 (2016)

PubMed id: 27933949

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.

A.Garzan, M.J.Willby, K.D.Green, C.S.Gajadeera, C.Hou, O.V.Tsodikov, J.E.Posey, S.Garneau-Tsodikova.

ABSTRACT

No abstract given.