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PDBsum entry 5hg0
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PDB id:
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Ligase
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Title:
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Crystal structure of pantoate-beta-alanine ligase from francisella tularensis complex with sam
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Structure:
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Pantothenate synthetase. Chain: a, b. Synonym: ps,pantoate--beta-alanine ligase,pantoate-activating enzyme. Engineered: yes. Other_details: n-terminal cloning artifact sna
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Source:
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Francisella tularensis subsp. Tularensis (strain schu s4 / schu 4). Organism_taxid: 177416. Strain: schu s4 / schu 4. Gene: panc, ftt_1390. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.40Å
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R-factor:
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0.187
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R-free:
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0.235
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Authors:
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C.Chang,N.Maltseva,Y.Kim,L.Papazisi,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)
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Key ref:
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C.Chang
et al.
Crystal structure of pantoate-Beta-Alanine ligase fro francisella tularensis comlex with sam.
To be published,
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Date:
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07-Jan-16
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Release date:
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20-Jan-16
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PROCHECK
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Headers
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References
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Q5NF57
(PANC_FRATT) -
Pantothenate synthetase from Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
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Seq:
Struc:
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261 a.a.
261 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.6.3.2.1
- pantoate--beta-alanine ligase (AMP-forming).
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Pathway:
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Coenzyme A Biosynthesis (early stages)
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Reaction:
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(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
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(R)-pantoate
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beta-alanine
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ATP
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=
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(R)-pantothenate
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+
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AMP
Bound ligand (Het Group name = )
matches with 56.25% similarity
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+
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diphosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
