PDBsum entry 5ezd

Hydrolase

PDB id: 5ezd

Contents

Protein chains

120 a.a.

Ligands

ACT ×2

Metals

__K ×2

Waters ×63

PDB id:

5ezd

Name:

Hydrolase

Title:

Crystal structure of a hepatocyte growth factor activator inhibitor-1 (hai-1) fragment covering the pkd-like 'internal' domain and kunitz domain 1

Structure:

Kunitz-type protease inhibitor 1. Chain: a, b. Fragment: unp residues 168-303. Synonym: hepatocyte growth factor activator inhibitor type 1,hai-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: spint1, hai1, unq223/pro256. Expressed in: komagataella pastoris cbs 7435. Expression_system_taxid: 981350

Resolution:

2.10Å R-factor: 0.222 R-free: 0.257

Authors:

Z.Hong,P.A.Andreasen,J.P.Morth,J.K.Jensen

Key ref:

Z.Hong et al. (2016). Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J Biol Chem, 291, 14340-14355. PubMed id: 27189939 DOI: 10.1074/jbc.M115.707240

Date:

26-Nov-15 Release date: 18-May-16

Protein chains

O43278  (SPIT1_HUMAN) -  Kunitz-type protease inhibitor 1 from Homo sapiens

Seq: 529 a.a.

Struc: 120 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DOI no: 10.1074/jbc.M115.707240

J Biol Chem 291:14340-14355 (2016)

PubMed id: 27189939

Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.

Z.Hong, L.De Meulemeester, A.Jacobi, J.S.Pedersen, J.P.Morth, P.A.Andreasen, J.K.Jensen.

ABSTRACT

No abstract given.