PDBsum entry 5e8f

Hydrolase

PDB id: 5e8f

Contents

Protein chains

147 a.a.

Ligands

LYS-SER-LYS-THR-CMT ×2

GER ×2

Waters ×108

PDB id:

5e8f

Name:

Hydrolase

Title:

Structure of fully modified geranylgeranylated pde6c peptide in complex with pde6d

Structure:

Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit delta. Chain: a, c. Fragment: unp residues 2-150. Synonym: gmp-pde delta,protein p17. Engineered: yes. Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha'. Chain: d, e.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde6d, pded. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pde6c, pdea2. Expression_system_taxid: 562

Resolution:

2.10Å R-factor: 0.201 R-free: 0.256

Authors:

E.K.Fansa,N.J.O'Reilly,S.A.Ismail,A.Wittinghofer

Key ref:

E.K.Fansa et al. (2015). The N- and C-terminal ends of RPGR can bind to PDE6δ. Embo Rep, 16, 1583-1585. PubMed id: 26553937 DOI: 10.15252/embr.201541404

Date:

14-Oct-15 Release date: 18-Nov-15

Protein chains

O43924  (PDE6D_HUMAN) -  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta from Homo sapiens

Seq: 150 a.a.

Struc: 147 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase.
• Reaction: 3',5'-cyclic GMP + H2O = GMP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.15252/embr.201541404

Embo Rep 16:1583-1585 (2015)

PubMed id: 26553937

The N- and C-terminal ends of RPGR can bind to PDE6δ.

E.K.Fansa, N.J.O'Reilly, S.Ismail, A.Wittinghofer.

ABSTRACT

No abstract given.