PDBsum entry 5dnx

Lyase

PDB id: 5dnx

Contents

Protein chains

176 a.a.

Ligands

5LD ×3

Metals

_MN ×6

Waters ×322

PDB id:

5dnx

Name:

Lyase

Title:

Crystal structure of igpd from pyrococcus furiosus in complex with (r)-c348

Structure:

Imidazoleglycerol-phosphate dehydratase. Chain: a, c, b. Synonym: igpd. Engineered: yes

Source:

Pyrococcus furiosus. Organism_taxid: 2261. Gene: hisb, pf1660. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.80Å R-factor: 0.132 R-free: 0.158

Authors:

C.Bisson,K.L.Britton,S.E.Sedelnikova,H.F.Rodgers,T.C.Eadsforth, R.C.Viner,T.R.Hawkes,P.J.Baker,D.W.Rice

Key ref:

C.Bisson et al. (2016). Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide. Angew Chem Int Ed Engl, 55, 13485-13489. PubMed id: 27717128 DOI: 10.1002/anie.201607185

Date:

10-Sep-15 Release date: 05-Oct-16

Protein chains

P58880  (HIS7_PYRFU) -  Imidazoleglycerol-phosphate dehydratase from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Seq: 176 a.a.

Struc: 176 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.19 - imidazoleglycerol-phosphate dehydratase.
• Pathway: Histidine Biosynthesis (late stages)
• Reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + H2O

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate (Bound ligand (Het Group name = 5LD) matches with 40.00% similarity) = 3-(imidazol-4-yl)-2- oxopropyl phosphate + H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1002/anie.201607185

Angew Chem Int Ed Engl 55:13485-13489 (2016)

PubMed id: 27717128

Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide.

C.Bisson, K.L.Britton, S.E.Sedelnikova, H.F.Rodgers, T.C.Eadsforth, R.C.Viner, T.R.Hawkes, P.J.Baker, D.W.Rice.

ABSTRACT

No abstract given.