PDBsum entry 5dbs

Hydrolase

PDB id: 5dbs

Contents

Protein chain

179 a.a.

Ligands

SO4

TMP

Metals

_MN

Waters ×16

PDB id:

5dbs

Name:

Hydrolase

Title:

2009 h1n1 pa endonuclease mutant e119d in complex with dtmp

Structure:

Polymerase acidic protein. Chain: a. Engineered: yes. Mutation: yes

Source:

Influenza a virus. Organism_taxid: 641501. Strain: swl a/california/04/2009 h1n1. Gene: pa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.11Å R-factor: 0.210 R-free: 0.241

Authors:

G.Kumar,S.W.White

Key ref:

M.S.Song et al. (2016). Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc Natl Acad Sci U S A, 113, 3669-3674. PubMed id: 26976575 DOI: 10.1073/pnas.1519772113

Date:

21-Aug-15 Release date: 23-Mar-16

Protein chain

C3W5S0  (C3W5S0_I09A0) -  Polymerase acidic protein from Influenza A virus (strain swl A/California/04/2009 H1N1)

Seq: 716 a.a.

Struc: 179 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.-.-

DOI no: 10.1073/pnas.1519772113

Proc Natl Acad Sci U S A 113:3669-3674 (2016)

PubMed id: 26976575

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.

M.S.Song, G.Kumar, W.R.Shadrick, W.Zhou, T.Jeevan, Z.Li, P.J.Slavish, T.P.Fabrizio, S.W.Yoon, T.R.Webb, R.J.Webby, S.W.White.

ABSTRACT

No abstract given.