PDBsum entry 5d9f

Transferase/transferase inhibitor

PDB id

5d9f

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Contents

			Protein chain

					237 a.a.

			Ligands

					58G

			Waters ×125

PDB id:

5d9f

Links

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of trmd, a m1g37 tRNA methyltransferase with sam- competitive compounds

Structure:

tRNA (guanine-n(1)-)-methyltransferase. Chain: a. Synonym: m1g-methyltransferase,tRNA [gm37] methyltransferase. Engineered: yes

Source:

Haemophilus influenzae. Organism_taxid: 71421. Strain: atcc 51907 / dsm 11121 / kw20 / rd. Gene: trmd, hi_0202. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.91Å

R-factor:

0.191

R-free:

0.220

Authors:

P.A.Elkins,W.G.Bonnette,K.P.Madauss

Key ref:

P.A.Elkins et al. Crystal structure of trmd, A m1g37 tRNA methyltransfe with sam-Competitive compounds. To be published, .

Date:

18-Aug-15

Release date:

31-Aug-16

PROCHECK

	Headers

	References

Protein chain

P43912 (TRMD_HAEIN) - tRNA (guanine-N(1)-)-methyltransferase from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Seq: Struc:					246 a.a. 237 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.2.1.1.228 - tRNA (guanine(37)-N(1))-methyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

guanosine₃₇ in tRNA + S-adenosyl-L-methionine = N₁- methylguanosine₃₇ in tRNA + S-adenosyl-L-homocysteine + H⁺

guanosine(37) in tRNA	+	S-adenosyl-L-methionine	=	N(1)- methylguanosine(37) in tRNA	+	S-adenosyl-L-homocysteine	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site