PDBsum entry 5cjs

Viral protein/immune system

PDB id: 5cjs

Contents

Protein chains

211 a.a.

217 a.a.

51 a.a.

143 a.a.

52 a.a.

156 a.a.

Ligands

NAG ×3

PDB id:

5cjs

Name:

Viral protein/immune system

Title:

Crystal structure of a monomeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody cr9114

Structure:

Cr9114 light chain. Chain: l, e. Engineered: yes. Cr9114 heavy chain. Chain: h, f. Engineered: yes. Designed influenza hemagglutinin stem #4454, ha1. Chain: c, j. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Synthetic construct. Organism_taxid: 32630. Expressed in: homo sapiens.

Resolution:

4.30Å R-factor: 0.264 R-free: 0.303

Authors:

X.Zhu,I.A.Wilson

Key ref:

A.Impagliazzo et al. (2015). A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science, 349, 1301-1306. PubMed id: 26303961 DOI: 10.1126/science.aac7263

Date:

15-Jul-15 Release date: 09-Sep-15

Protein chains

No UniProt id for this chain

Struc: 211 a.a.

Protein chains

No UniProt id for this chain

Struc: 217 a.a.

Protein chain

No UniProt id for this chain

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 143 a.a.

Protein chain

No UniProt id for this chain

Struc: 52 a.a.

Protein chain

No UniProt id for this chain

Struc: 156 a.a.

DOI no: 10.1126/science.aac7263

Science 349:1301-1306 (2015)

PubMed id: 26303961

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen.

A.Impagliazzo, F.Milder, H.Kuipers, M.V.Wagner, X.Zhu, R.M.Hoffman, R.van Meersbergen, J.Huizingh, P.Wanningen, J.Verspuij, M.de Man, Z.Ding, A.Apetri, B.Kükrer, E.Sneekes-Vriese, D.Tomkiewicz, N.S.Laursen, P.S.Lee, A.Zakrzewska, L.Dekking, J.Tolboom, L.Tettero, S.van Meerten, W.Yu, W.Koudstaal, J.Goudsmit, A.B.Ward, W.Meijberg, I.A.Wilson, K.Radošević.

ABSTRACT

No abstract given.