PDBsum entry 5cc7

Transferase

PDB id: 5cc7

Contents

Protein chain

704 a.a.

Ligands

1F1

Metals

_MG

Waters ×726

PDB id:

5cc7

Name:

Transferase

Title:

Crystal structure of mycobacterium tuberculosis malate synthase in complex with 1h-indole-6-carboxylic acid

Structure:

Malate synthase g. Chain: a. Engineered: yes. Mutation: yes

Source:

Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: glcb, rv1837c, mtcy1a11.06. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.12Å R-factor: 0.189 R-free: 0.252

Authors:

H.-L.Huang,J.C.Sacchettini

Key ref:

H.-L.Huang et al. Crystal structures of fragment-Bound malate synthase mycobacterium tuberculosis provide insights into mech and potential inhibitor designs. To be published, .

Date:

01-Jul-15 Release date: 10-Aug-16

Protein chain

P9WK17  (MASZ_MYCTU) -  Malate synthase G from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 741 a.a.

Struc: 704 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.3.3.9 - malate synthase.
• Pathway: Glyoxylate Cycle
• Reaction: glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H⁺

glyoxylate + acetyl-CoA + H2O = (S)-malate (Bound ligand (Het Group name = 1F1) matches with 40.00% similarity) + CoA + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site