PDBsum entry 5ca0

Structural protein

PDB id: 5ca0

Contents

Protein chains

437 a.a.

426 a.a.

121 a.a.

334 a.a.

Ligands

GTP ×2

GOL

GDP ×2

MES

LXL ×2

ACP

Metals

_CA ×2

_MG ×3

Waters ×171

PDB id:

5ca0

Name:

Structural protein

Title:

Crystal structure of t2r-ttl-lexibulin complex

Structure:

Tubulin alpha-1b chain. Chain: a, c. Synonym: alpha-tubulin ubiquitous,tubulin k-alpha-1,tubulin alpha- ubiquitous chain. Uncharacterized protein. Chain: b, d. Synonym: tubulin beta-2b chain. Stathmin-4. Chain: e.

Source:

Sus scrofa. Pig. Organism_taxid: 9823. Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: stmn4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.50Å R-factor: 0.200 R-free: 0.237

Authors:

Y.Wang,Y.Yu,Q.Chen,J.Yang

Key ref:

Y.Wang et al. (2016). Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J, 283, 102-111. PubMed id: 26462166 DOI: 10.1111/febs.13555

Date:

29-Jun-15 Release date: 04-Nov-15

Protein chains

Q2XVP4  (TBA1B_PIG) -  Tubulin alpha-1B chain from Sus scrofa

Seq: 451 a.a.

Struc: 437 a.a.

Protein chains

F2Z5B2  (F2Z5B2_PIG) -  Tubulin beta chain from Sus scrofa

Seq: 425 a.a.

Struc: 426 a.a.*

Protein chain

P63043  (STMN4_RAT) -  Stathmin-4 from Rattus norvegicus

Seq: 189 a.a.

Struc: 121 a.a.

Protein chain

	E1BQ43  (E1BQ43_CHICK) -
	* PDB and UniProt seqs differ at 11 residue positions (black crosses)

DOI no: 10.1111/febs.13555

Febs J 283:102-111 (2016)

PubMed id: 26462166

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.

Y.Wang, H.Zhang, B.Gigant, Y.Yu, Y.Wu, X.Chen, Q.Lai, Z.Yang, Q.Chen, J.Yang.

ABSTRACT

No abstract given.