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PDBsum entry 5c6f

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
5c6f

 

 

 

 

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Contents
Protein chains
(+ 6 more) 172 a.a.
Ligands
IMD ×11
Metals
_FE ×9
Waters ×2473
PDB id:
5c6f
Name: Oxidoreductase
Title: Crystal structures of ferritin mutants reveal side-on binding to diiron and end-on cleavage of oxygen
Structure: Bacterial non-heme ferritin. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Engineered: yes. Mutation: yes
Source: Helicobacter pylori. Organism_taxid: 85963. Strain: j99 / atcc 700824. Gene: ftna, pfr, jhp_0598. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.00Å     R-factor:   0.151     R-free:   0.195
Authors: S.Kim,K.H.Kim,J.H.Seok,Y.H.Park,S.W.Jung,Y.B.Chung,D.B.Lee,J.H.Lee, K.R.Han,A.E.Cho,C.Lee,M.S.Chung
Key ref: S.Kim et al. (2016). Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria. J Mol Biol, 428, 5007-5018. PubMed id: 27777002 DOI: 10.1016/j.jmb.2016.10.022
Date:
23-Jun-15     Release date:   27-Jul-16    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9ZLI1  (FTN_HELPJ) -  Bacterial non-heme ferritin from Helicobacter pylori (strain J99 / ATCC 700824)
Seq:
Struc:
167 a.a.
172 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.16.3.2  - bacterial non-heme ferritin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 Fe2+ + O2 + 6 H2O = 4 iron(III) oxide-hydroxide + 12 H+
4 × Fe(2+)
+ O2
+ 6 × H2O
= 4 × iron(III) oxide-hydroxide
+ 12 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Key reference    
 
 
DOI no: 10.1016/j.jmb.2016.10.022 J Mol Biol 428:5007-5018 (2016)
PubMed id: 27777002  
 
 
Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria.
S.Kim, J.H.Lee, J.H.Seok, Y.H.Park, S.W.Jung, A.E.Cho, C.Lee, M.S.Chung, K.H.Kim.
 
  ABSTRACT  
 
No abstract given.

 

 

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