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PDBsum entry 5c0r
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protein ligands Protein-protein interface(s) links
Viral protein/immune system PDB id
5c0r

 

 

 

 

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Contents
Protein chains
270 a.a.
214 a.a.
222 a.a.
Ligands
NAG-NAG
NAG
Waters ×8
PDB id:
5c0r
Name: Viral protein/immune system
Title: Crystal structure of a generation 3 influenza hemagglutinin stabilized stem complexed with the broadly neutralizing antibody c179
Structure: Hemagglutinin, envelope glycoprotein, fibritin fusion protein. Chain: a. Fragment: unp q6wg00 residues 18-49, 328-402, 436-517, unp p04578 residues 546-577, 628-654 and unp d9iej2 residues 458-485. Engineered: yes. C179 fab light chain. Chain: l. Engineered: yes.
Source: Influenza a virus, human immunodeficiency virus type 1 group m subtype b, enterobacteria phage t4. Organism_taxid: 381512, 11706, 10665. Strain: a/new caledonia/20/1999(h1n1), isolate hxb2. Gene: ha, env, wac. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Expression_system_organ: kidney.
Resolution:
3.19Å     R-factor:   0.202     R-free:   0.251
Authors: J.C.Boyington,P.D.Kwong,G.J.Nabel,J.R.Mascola
Key ref: H.M.Yassine et al. (2015). Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat Med, 21, 1065-1070. PubMed id: 26301691 DOI: 10.1038/nm.3927
Date:
12-Jun-15     Release date:   02-Sep-15    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
D9IEJ2  (D9IEJ2_BPT4) -  Fibritin from Enterobacteria phage T4
Seq:
Struc: 		487 a.a.
270 a.a.*
Protein chain
Pfam   ArchSchema ?
P04578  (ENV_HV1H2) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
Seq:
Struc: 		 
Seq:
Struc: 		856 a.a.
270 a.a.*
Protein chain
Pfam   ArchSchema ?
Q6WG00  (Q6WG00_9INFA) -  Hemagglutinin from Influenza A virus
Seq:
Struc: 		 
Seq:
Struc: 		565 a.a.
270 a.a.*
Protein chain
No UniProt id for this chain
Struc: 214 a.a.
Protein chain
No UniProt id for this chain
Struc: 222 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 568 residue positions (black crosses)

 

 
DOI no: 10.1038/nm.3927 Nat Med 21:1065-1070 (2015)
PubMed id: 26301691  
 
 
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.
H.M.Yassine, J.C.Boyington, P.M.McTamney, C.J.Wei, M.Kanekiyo, W.P.Kong, J.R.Gallagher, L.Wang, Y.Zhang, M.G.Joyce, D.Lingwood, S.M.Moin, H.Andersen, Y.Okuno, S.S.Rao, A.K.Harris, P.D.Kwong, J.R.Mascola, G.J.Nabel, B.S.Graham.
 
  ABSTRACT  
 
No abstract given.

 

 

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