X-ray crystal structure of aplysia californica acetylcholine binding protein (ac-achbp) y55w in complex with 2-pyridin-3-yl-1-aza- bicyclo[2.2.2]octane; 2-(3-pyridyl)quinuclidine; 2-pq (ti-4699)
Structure:
Soluble acetylcholine receptor. Chain: a, b, c, d, e. Fragment: unp residues 18-236. Engineered: yes. Mutation: yes
Source:
Aplysia californica. California sea hare. Organism_taxid: 6500. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek gnt1-. Expression_system_atcc_number: crl-3022
Resolution:
2.27Å
R-factor:
0.186
R-free:
0.222
Authors:
J.Bobango,B.Sankaran,J.F.Park,J.Wu,T.T.Talley
Key ref:
J.Bobango
et al.
Comparisons of binding affinities for neuronal nicoti receptors (nnrs) and achbps.
To be published,
.
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