PDBsum entry 5b8c

Immune system

PDB id: 5b8c

Contents

Protein chains

111 a.a.

120 a.a.

116 a.a.

Waters ×271

PDB id:

5b8c

Name:

Immune system

Title:

High resolution structure of the human pd-1 in complex with pembrolizumab fv

Structure:

Pembrolizumab light chain variable region (pemvl). Chain: a, d, g, j. Engineered: yes. Pembrolizumab heavy chain variable region (pemvh). Chain: b, e, h, k. Engineered: yes. Programmed cell death protein 1. Chain: c, f, i, l. Synonym: hpd-1.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: brevibacillus choshinensis. Expression_system_taxid: 54911. Human. Gene: pdcd1, pd1. Expression_system_taxid: 54911

Resolution:

2.15Å R-factor: 0.186 R-free: 0.226

Authors:

S.Horita,T.Shimamura,S.Iwata,N.Nomura

Key ref:

S.Horita et al. (2016). High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. Sci Rep, 6, 35297. PubMed id: 27734966 DOI: 10.1038/srep35297

Date:

14-Jun-16 Release date: 26-Oct-16

Protein chains

No UniProt id for this chain

Struc: 111 a.a.

Protein chains

No UniProt id for this chain

Struc: 120 a.a.

Protein chains

Q15116  (PDCD1_HUMAN) -  Programmed cell death protein 1 from Homo sapiens

Seq: 288 a.a.

Struc: 116 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

DOI no: 10.1038/srep35297

Sci Rep 6:35297 (2016)

PubMed id: 27734966

High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1.

S.Horita, Y.Nomura, Y.Sato, T.Shimamura, S.Iwata, N.Nomura.

ABSTRACT

No abstract given.