PDBsum entry 5b4x

Signaling protein/endocytosis

PDB id: 5b4x

Contents

Protein chains

710 a.a.

479 a.a.

Ligands

NAG ×5

Metals

_CA ×16

PDB id:

5b4x

Name:

Signaling protein/endocytosis

Title:

Crystal structure of the apoer2 ectodomain in complex with the reelin r56 fragment

Structure:

Reelin. Chain: a, c. Fragment: unp residues 1948-2662. Synonym: reeler protein. Engineered: yes. Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, isoform cra_e. Chain: b, d. Fragment: apoer2 ectodomain (unp residues 42-607).

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: reln, rl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

3.20Å R-factor: 0.203 R-free: 0.255

Authors:

N.Yasui,H.Hirai,K.Yamashita,J.Takagi,T.Nogi

Key ref:

H.Hirai et al. Crystal structure of the ectodomain from a ldlr close homologue in complex with its physiological ligand.. To be published, .

Date:

20-Apr-16 Release date: 26-Apr-17

Protein chains

Q60841  (RELN_MOUSE) -  Reelin from Mus musculus

Seq: 3461 a.a.

Struc: 710 a.a.*

Protein chains

Q14114  (LRP8_HUMAN) -  Low-density lipoprotein receptor-related protein 8 from Homo sapiens

Seq: 963 a.a.

Struc: 479 a.a.*

* PDB and UniProt seqs differ at 50 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, C: E.C.3.4.21.- - ?????