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PDBsum entry 5kos
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Hydrolase/hydrolase inhibitor
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PDB id
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5kos
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PDB id:
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| Name: |
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Hydrolase/hydrolase inhibitor
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Title:
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Discovery of tak-272: a novel, potent and orally active renin in- hibitor
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Structure:
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Renin. Chain: a, b. Fragment: unp residues 70-406. Synonym: angiotensinogenase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ren. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293
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Resolution:
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2.41Å
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R-factor:
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0.187
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R-free:
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0.230
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Authors:
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G.P.Snell,C.A.Behnke,K.Okada,O.Hideyuki,B.-C.Sang,W.Lane
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Key ref:
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Y.Imaeda
et al.
(2016).
Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.
Acs Med Chem Lett,
7,
933-938.
PubMed id:
DOI:
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Date:
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01-Jul-16
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Release date:
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16-Nov-16
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PROCHECK
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Headers
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References
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P00797
(RENI_HUMAN) -
Renin from Homo sapiens
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Seq:
Struc:
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406 a.a.
331 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.4.23.15
- renin.
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Reaction:
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Cleaves Leu-|- bond in angiotensinogen to generate angiotensin I.
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DOI no:
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Acs Med Chem Lett
7:933-938
(2016)
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PubMed id:
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Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.
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Y.Imaeda,
H.Tokuhara,
Y.Fukase,
R.Kanagawa,
Y.Kajimoto,
K.Kusumoto,
M.Kondo,
G.Snell,
C.A.Behnke,
T.Kuroita.
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ABSTRACT
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Links
