PDBsum entry 5i3r

Transferase/transferase inhibitor

PDB id: 5i3r

Contents

Protein chains

302 a.a.

Ligands

IDK ×2

PO4 ×2

Waters ×192

PDB id:

5i3r

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of bmp-2-inducible kinase in complex with an indazole inhibitor

Structure:

Bmp-2-inducible protein kinase. Chain: a, b. Synonym: bike. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2k, bike, hrihfb2017. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.40Å R-factor: 0.188 R-free: 0.231

Authors:

R.M.Counago,F.J.Sorrell,T.Krojer,P.Savitsky,J.M.Elkins,A.Axtman, D.Drewry,C.Wells,C.Zhang,W.Zuercher,T.M.Willson,C.H.Arrowsmith, A.M.Edwards,C.Bountra,P.Arruda,O.Gileadi,Structural Genomics Consortium (Sgc)

Key ref:

R.M.Counago et al. Crystal structure of bmp-2-Inducible kinase in comple an indazole inhibitor. To be published, .

Date:

10-Feb-16 Release date: 09-Mar-16

Protein chains

Q9NSY1  (BMP2K_HUMAN) -  BMP-2-inducible protein kinase from Homo sapiens

Seq: 1161 a.a.

Struc: 302 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site