PDBsum entry 5hw3

Hydrolase

PDB id: 5hw3

Contents

Protein chain

269 a.a.

Ligands

SO4 ×8

ACT ×3

Waters ×280

PDB id:

5hw3

Name:

Hydrolase

Title:

Crystal structure of a beta lactamase from burkholderia vietnamiensis

Structure:

Beta-lactamase. Chain: a. Engineered: yes

Source:

Burkholderia vietnamiensis. Organism_taxid: 269482. Strain: g4 / lmg 22486. Gene: bcep1808_4738. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.45Å R-factor: 0.131 R-free: 0.162

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

K.T.Potts et al. Crystal structure of a beta lactamase from burkholder vietnamiensis. To be published, .

Date:

29-Jan-16 Release date: 10-Feb-16

Protein chain

A4JN42  (A4JN42_BURVG) -  Beta-lactamase from Burkholderia vietnamiensis (strain G4 / LMG 22486)

Seq: 291 a.a.

Struc: 269 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)