PDBsum entry 5euc

Transferase

PDB id: 5euc

Contents

Protein chains

197 a.a.

Waters ×111

PDB id:

5euc

Name:

Transferase

Title:

The role of thE C-terminal region on the oligomeric state and enzymatic activity of trypanosoma cruzi hypoxanthine phosphoribosyl transferase

Structure:

Hypoxanthine-guanine phosphoribosyltransferase. Chain: a, b, c, d. Fragment: unp residues 21-241. Engineered: yes

Source:

Trypanosoma cruzi (strain cl brener). Organism_taxid: 353153. Strain: cl brener. Gene: tc00.1047053509693.70. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

2.65Å R-factor: 0.193 R-free: 0.264

Authors:

W.M.Valsecchi,A.Cousido-Siah,A.Mitschler,A.Podjarny,J.M.Delfino, J.Santos

Key ref:

W.M.Valsecchi et al. (2016). The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase. Biochim Biophys Acta, 1864, 655-666. PubMed id: 26969784 DOI: 10.1016/j.bbapap.2016.03.005

Date:

18-Nov-15 Release date: 30-Mar-16

Protein chains

Q4DRC4  (Q4DRC4_TRYCC) -  Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi (strain CL Brener)

Seq: 241 a.a.

Struc: 197 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.8 - hypoxanthine phosphoribosyltransferase.
• Reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1016/j.bbapap.2016.03.005

Biochim Biophys Acta 1864:655-666 (2016)

PubMed id: 26969784

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.

W.M.Valsecchi, A.Cousido-Siah, L.A.Defelipe, A.Mitschler, A.Podjarny, J.Santos, J.M.Delfino.

ABSTRACT

No abstract given.