PDBsum entry 5ejc

Signaling protein

PDB id: 5ejc

Contents

Protein chains

268 a.a.

31 a.a.

34 a.a.

32 a.a.

39 a.a.

PDB id:

5ejc

Name:

Signaling protein

Title:

Crystal structural of the tsc1-tbc1d7 complex

Structure:

Tbc1 domain family member 7. Chain: a, b. Fragment: unp residues 18-293. Synonym: cell migration-inducing protein 23. Engineered: yes. Hamartin. Chain: c, d, e, f. Fragment: unp residues 939-992. Synonym: tuberous sclerosis 1 protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tbc1d7, tbc7, hspc239. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tsc1, kiaa0243, tsc. Expression_system_taxid: 562

Resolution:

3.10Å R-factor: 0.221 R-free: 0.239

Authors:

Z.Wang,J.Qin,W.Gong,W.Xu

Key ref:

J.Qin et al. (2016). Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7). J Biol Chem, 291, 8591-8601. PubMed id: 26893383 DOI: 10.1074/jbc.M115.701870

Date:

01-Nov-15 Release date: 02-Mar-16

Protein chains

Q9P0N9  (TBCD7_HUMAN) -  TBC1 domain family member 7 from Homo sapiens

Seq: 293 a.a.

Struc: 268 a.a.

Protein chain

Q92574  (TSC1_HUMAN) -  Hamartin from Homo sapiens

Seq: 1164 a.a.

Struc: 31 a.a.

Protein chain

Q92574  (TSC1_HUMAN) -  Hamartin from Homo sapiens

Seq: 1164 a.a.

Struc: 34 a.a.*

Protein chain

Q92574  (TSC1_HUMAN) -  Hamartin from Homo sapiens

Seq: 1164 a.a.

Struc: 32 a.a.

Protein chain

Q92574  (TSC1_HUMAN) -  Hamartin from Homo sapiens

Seq: 1164 a.a.

Struc: 39 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1074/jbc.M115.701870

J Biol Chem 291:8591-8601 (2016)

PubMed id: 26893383

Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7).

J.Qin, Z.Wang, M.Hoogeveen-Westerveld, G.Shen, W.Gong, M.Nellist, W.Xu.

ABSTRACT

No abstract given.