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PDBsum entry 5e5u
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protein ligands Protein-protein interface(s) links
Cell adhesion/hydrolase PDB id
5e5u

 

 

 

 

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Contents
Protein chains
264 a.a.
199 a.a.
Ligands
1PS ×4
FMT ×3
MLI
ACY ×2
MLT ×4
Waters ×535
PDB id:
5e5u
Name: Cell adhesion/hydrolase
Title: Crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn6
Structure: Receptor-type tyrosine-protein phosphatase gamma. Chain: a, c. Fragment: ca domain, unp residues 57-320. Synonym: r-ptp-gamma. Engineered: yes. Contactin-6. Chain: b, d. Fragment: immunoglobulin domains 2-3, unp residues 119-316. Synonym: neural recognition molecule nb-3,mnb-3.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptprg. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cntn6.
Resolution:
2.00Å     R-factor:   0.170     R-free:   0.217
Authors: R.M.Nikolaienko,S.Bouyain
Key ref: R.M.Nikolaienko et al. (2016). Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J Biol Chem, 291, 21335-21349. PubMed id: 27539848 DOI: 10.1074/jbc.M116.742163
Date:
09-Oct-15     Release date:   31-Aug-16    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05909  (PTPRG_MOUSE) -  Receptor-type tyrosine-protein phosphatase gamma from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1442 a.a.
264 a.a.
Protein chains
Pfam   ArchSchema ?
Q9JMB8  (CNTN6_MOUSE) -  Contactin-6 from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1028 a.a.
199 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains A, C: E.C.3.1.3.48  - protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
O-phospho-L-tyrosyl-[protein]
 + H2O
 = L-tyrosyl-[protein]
 + phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Key reference    
 
 
DOI no: 10.1074/jbc.M116.742163 J Biol Chem 291:21335-21349 (2016)
PubMed id: 27539848  
 
 
Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
R.M.Nikolaienko, M.Hammel, V.Dubreuil, R.Zalmai, D.R.Hall, N.Mehzabeen, S.J.Karuppan, S.Harroch, S.L.Stella, S.Bouyain.
 
  ABSTRACT  
 
No abstract given.

 

 

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